Dopamine Effects on Circulation and Myocardial Oxygen Supply

The Hemodynamic Effects of Drugs on Myocardial Oxygen Use

The circulatory responses to high equinalgesic doses of morphine are compared with those of pethidin. The decrease in mean arterial blood pressure in case of morphine was 28p.c., with a paralleled and identical de­crease in total peripheral resistance and no negative inotropic effects.  Pethidine decreased blood pressure 54p.c., as a result of peripheral vasodilation of 46p.c. and a sharp drop...

Perfusion of the isolated trout heart coronary circulation with red blood cells: effects of oxygen supply and nitrite on coronary flow and myocardial oxygen consumption.

A method for perfusion of the isolated trout heart coronary circulation with red blood cells (RBCs) was developed. The method was used to analyse the influence of RBC perfusion on myocardial O(2) supply and O(2) consumption and to test the hypothesis that nitrite is converted to vasoactive nitric oxide in the RBC-perfused coronary circulation. Perfusion with RBCs significantly increased myocard...

[Effects of circulation on oxygen poisoning].

Effects of hyperbaric oxygen on uteroplacental and fetal circulation.

The effects of hyperbaric oxygen (at 3 atmospheres absolute) on uteroplacental and fetal circulations were studied in pregnant ewes near term. The ewe was given spinal anesthesia, the fetus was marsupialized to the abdominal walls to protect the umbilical circulation, and the fetal head was covered with a saline-filled glove to prevent breathing. During hyperbaric oxygenation, maternal arterial...

Studies on digitalis. XVI. Effects on myocardial oxygen consumption.

The effects of cardiac glycosides on myocardial oxygen consumption (MVo2) have been investigated extensively, and although the results of these studies have not been entirely uniform, it is now generally considered that these agents are "the only drugs which increase the force of contraction of the myocardium without at the same time increasing oxygen consumption" (1). The finding in previous i...